自Beeson等从中性粒细胞中提纯一种称为“白细胞热原”的致热物质后,使人们对热原引起发热的认识进入了新阶段。随后,有学者证明单核细胞、组织巨噬细胞等也能产生同样致热物质,目前,统称为“内源性热原”。一般认为来源于骨髓的吞噬细胞才能释放内源性热原。外源性热原包括微生物类和非微生物类。除少数例外,极大部分外源性热原进入机体后,首先激活细胞产生和释放内源性热原进入血流,到达下丘脑体温调节中枢,使调定点提高,体温上升而产生发热反应。外源性热原如内毒素在化学性质等方面与内源性热原是不同的。其主要区别 Since Beeson et al. Purified a neutrophil called “leukocyte pyrogen,” the pyrogenic substance, making people aware of fever caused by pyrogen has entered a new phase. Subsequently, some scholars have proved that monocytes, macrophages and other tissue can also produce the same pyrogenic substances, at present, collectively referred to as “endogenous pyrogen.” It is generally believed that bone marrow-derived phagocytes release endogenous pyrogen. Exogenous pyrogen includes microorganisms and non-microorganisms. With a few exceptions, the vast majority of exogenous pyrogen into the body, the first activation of cell production and release of endogenous pyrogen into the bloodstream, reaching the hypothalamic thermoregulatory center, so that the set point increases, the body temperature rise and fever response. Exogenous pyrogen, such as endotoxin in the chemical nature of endogenous pyrogen is different. The main difference