[Objective] The study aimed to discuss the preparation process of Epigallocatechin-3-gallate (EGCG) effervescent tablets. [Method] Various raw materials were dried for different time at 50 ℃, and then the sticking degree of EGCG effervescent tablets was reviewed. Hereafter, the formula of EGCG effervescent tablets was optimized by orthogonal test. [Result] Effervescent tablets without sticking were smooth after being dried for 150 min. The optimal formula of EGCG effervescent tablets was composed of 4% EGCG, 45% citric acid and sodium carbonate (Citric acid∶Sodium carbonate = 1.6∶1), 20% lactose, 4% L-leucine, 4% sodium cyclamate and 23% orange powder. [Conclusion] The prepared EGCG effervescent tablets without sticking has a good effervescence effect and taste. [Objective] The study aimed to discuss the preparation process of Epigallocatechin-3-gallate (EGCG) effervescent tablets. [Method] Various raw materials were dried for different times at 50 ° C, and then the sticking degree of EGCG effervescent tablets was reviewed. The results of EGCG effervescent tablets were optimized by orthogonal test. [Result] Effervescent tablets without sticking were smooth after being for 150 min. The optimal formula of EGCG effervescent tablets was composed of 4% EGCG, 45% citric acid and sodium 20% lactose, 4% L-leucine, 4% sodium cyclamate and 23% orange powder. [Conclusion] The prepared EGCG effervescent tablets without sticking has a good effervescence effect and taste .