论文部分内容阅读
本文论述了骨、软骨组织工程构建中支架的影像学设计和制作方法。我们的组织工程化骨和 (或 )软骨支架为三维设计制作的生物可降解支架 ,按颌面部重建部位进行个体化设计。这种经过特制的支架能够将生物刺激传入位于其间隙内的种植细胞。这些生物刺激信号可影响植入支架内的间充质干细胞 (MSC)或骨髓基质细胞(BMSC) ,从而形成面部重建所需的组织。这种颌面部组织工程新技术具有优点 ,一方面符合重建位的解剖形态 ;另一方面能够在行使功能时 ,适应功能力量而发生改建。本文以颞下颌关节 (TMJ)髁突 -升支区重建为例 ,对这一新技术作一详细介绍。
This article discusses the imaging design and fabrication of stents in the construction of bone and cartilage tissue engineering. Our tissue-engineered bone and / or cartilage scaffolds are three-dimensional designed biodegradable scaffolds that are individually designed for maxillofacial reconstruction. This specially crafted stent enables biostimulation to be introduced into the planting cells located in their gaps. These biostimulatory signals can affect mesenchymal stem cells (MSCs) or bone marrow stromal cells (BMSCs) implanted in scaffolds to form the tissue required for facial reconstruction. This new technique of maxillofacial tissue engineering has the advantage that on the one hand, it meets the anatomical shape of the reconstruction site; on the other hand, it can be adapted to the functional forces and remodeled while exercising the function. In this paper, the temporomandibular joint (TMJ) condylar - ascending branch area reconstruction as an example, a detailed introduction of this new technology.