目的：观察香菇多糖治疗原发性肝癌的疗效。方法：１２８例原发性肝癌患者随机分为两组，Ａ组６０例，单纯应用肝动脉化疗栓塞术（ＴＡＥ）；Ｂ组６８例，应用ＴＡＥ＋香菇多糖联合治疗。结果：肿瘤减小率Ａ组为１３３％，Ｂ组为５４４％（Ｐ＜００１）。ＡＦＰ降低率，Ａ组为１０４％，Ｂ组为２３１％（Ｐ＜００１）。结论：ＴＡＥ＋香菇多糖联合治疗可以调节机体免疫功能，对原发性肝癌的治疗效果明显优于单纯ＴＡＥ。 Objective: To observe the efficacy of lentinan in the treatment of primary liver cancer. Methods: 128 patients with primary liver cancer were randomly divided into two groups. 60 patients in group A were treated with hepatic arterial chemoembolization (TAE) alone; 68 patients in group B were treated with TAE plus lentinan. Results: The tumor reduction rate was 13.3% in group A and 54.4% in group B (P<001). The AFP reduction rate was 10.4% in group A and 23.1% in group B (P<001). Conclusion: TAE combined with lentinan can regulate the immune function of the body, and its therapeutic effect on primary hepatocellular carcinoma is obviously better than that of TAE alone.