A 3D femoral model was built to obtain the three?dimensional temperature distribution of femur and its surrounding tissues and provide references for clinical applications. According to the relationship between gray?value and material properties, the model was assigned with various materials to make sure that it is more similar to the real femur in geometry and physical properties. 3D temperature distribution is obtained by using finite element analysis software ANSYS 11?0 on the basis of heat conduction theory, Laplace equation, Pennes bio?heat transfer equation, thermo physical parameters of bone tissues, the boundary condition, and initial conditions. Taken the asymmetry of the 3D distribution of temperature into account, it is necessary to adopt the heating method with multiple heat sources. This method can ensure that the temperature fields match well with the tumor tissues and kill the tumor cells efficiently under the condition of protecting the normal tissues from damage. The analysis results supply important guidance for determining the needle position and the needle number and controlling the intensity of heating.