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目的观察1,6-二磷酸果糖(1,6-FDP)治疗新生儿缺氧缺血性脑病(HIE)的疗效。方法将60例HIE的新生儿随机分为治疗组和对照组,两组均为30例,对照组给予常规治疗,治疗组在常规治疗基础上加用1,6-二磷酸果糖250mg/(kg.d)静脉滴注,疗程为10～14d。观察两组患儿临床症状、体征,包括意识、原始反射、惊厥、肌张力恢复情况,并于生后第3天、7天、14天行新生儿神经行为评分(NBNA)。结果治疗组30例临床症状、体征恢复时间明显短于对照组,NBNA评分优于对照组,差异有统计学意义,未发现该药的不良反应。结论 1,6-二磷酸果糖治疗新生儿HIE疗效肯定,值得临床推广应用。
Objective To observe the therapeutic effect of fructose-1,6-diphosphate (1,6-FDP) on neonatal hypoxic-ischemic encephalopathy (HIE). Methods Sixty neonates with HIE were randomly divided into treatment group and control group, with 30 cases in both groups. The control group was given routine treatment. The treatment group was given conventional treatment with fructose-1,6-diphosphate 250mg / (kg d) intravenous infusion, treatment for 10 ~ 14d. The clinical symptoms and signs, including consciousness, primary reflex, convulsion and muscle tone recovery were observed in two groups. Neonatal neurobehavioral score (NBNA) was also measured on the 3rd, 7th and 14th day after birth. Results The clinical symptoms and signs recovery time of the 30 cases in the treatment group were significantly shorter than those in the control group. The NBNA score was better than that in the control group. The difference was statistically significant and no adverse reactions were found. Conclusion 1,6-diphosphate fructose treatment of neonatal HIE positive effect, worthy of clinical application.