论文部分内容阅读
[目的]观察复方嗜酸乳杆菌片治疗小儿β-内酰胺类抗生素相关性腹泻的临床疗效,以及该药对提高患儿免疫功能的作用。[方法]96例β-内酰胺类抗生素相关性腹泻患儿,随机分为2组,各48例。治疗组患儿给予复方嗜酸乳杆菌片治疗,对照组患儿给予蒙脱石散(思密达)。观察2组患儿服药后的大便次数、性状等指标,比较其疗效的差异。[结果]治疗组总有效率为93.7%,对照组总有效率为66.7%,差异有统计学意义(P<0.05)。用药后治疗组血清免疫球蛋白IgA为(1.52±0.34),对照组为(1.35±0.29),2组间差异有统计学意义(P<0.05)。[结论]复方嗜酸乳杆菌片治疗小儿β-内酰胺类抗生素相关性腹泻疗效显著,并可在一定程度上提高患儿免疫力,值得临床推广。
[Objective] To observe the clinical efficacy of compound acidophilus Lactobacillus tablets in treating children’s β-lactam antibiotic-associated diarrhea and the effect of the drug on improving immune function in children. [Method] Ninety-six children with β-lactam antibiotic-associated diarrhea were randomly divided into 2 groups (n = 48). Children in the treatment group were given Lactobacillus acidophilus tablets, while those in the control group were given montmorillonite powder (Smectite). Observed two groups of children after taking stool frequency, traits and other indicators, to compare the differences in their efficacy. [Results] The total effective rate was 93.7% in the treatment group and 66.7% in the control group, the difference was statistically significant (P <0.05). After treatment, serum immunoglobulin IgA was (1.52 ± 0.34) in the treatment group and (1.35 ± 0.29) in the control group, with significant difference between the two groups (P <0.05). [Conclusion] The compound Lactobacillus acidophilus tablet has a significant effect on the treatment of β-lactam antibiotic-associated diarrhea in children, and can improve children’s immunity to a certain extent, which deserves clinical promotion.