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目的分析甘肃省武威市肺结核病耐药监测结果,为今后制定结核病防治规划提供科学依据。方法培养痰涂片阳性肺结核病患者的痰液并鉴定结核分枝杆菌菌种,培养阳性的结核分枝杆菌采用比例法药物敏感性试验判断患者是否耐药;应用Epi Data 3.1建立数据库,采用Spss 13.0软件进行统计学分析。结果涂阳肺结核病患者性别构成差异无统计学意义(χ2=1.60,P>0.05);男性患者以青壮年人群为主,不同年龄构成差异有统计学意义(χ2=5.68,P<0.05);女性患者以老年人群为主,不同年龄构成差异有统计学意义(χ2=3.85,P<0.05);涂阳肺结核病患者以新发患者为主,病例构成差异有统计学意义(χ2=68.29,P<0.05);复治失败患者耐药率最高,不同患者耐药率差异有统计学意义(χ2=14.85,P<0.05)。结论武威市肺结核病耐药情况较为严重,需及早预防耐多药肺结核病的发生和流行,应尽快制定耐药肺结核病患者的免费住院治疗政策。
Objective To analyze the results of drug resistance surveillance of tuberculosis in Wuwei City, Gansu Province, and to provide a scientific basis for the future development of tuberculosis prevention and control plan. Methods The sputum smear-positive pulmonary tuberculosis patients were cultured and the mycobacterium tuberculosis strains were identified. The positive Mycobacterium tuberculosis strains were cultured to determine whether the patients were resistant by proportional drug sensitivity test. The database was constructed by using Epi Data 3.1 and Spss 13.0 software for statistical analysis. Results There was no significant difference in gender composition between smear - positive pulmonary tuberculosis patients (χ2 = 1.60, P> 0.05). Male patients were mainly young and middle - aged people with different age groups (χ2 = 5.68, P <0.05). Female patients were mainly elderly people with different age groups (χ2 = 3.85, P <0.05). Patients with smear positive pulmonary tuberculosis were mainly new patients with a statistically significant difference in the cases (χ2 = 68.29, P <0.05). The rate of drug resistance was the highest in patients with failed retreatment, and there was significant difference in drug resistance among different patients (χ2 = 14.85, P <0.05). Conclusion The drug resistance of tuberculosis is more serious in Wuwei City. Therefore, it is necessary to prevent the occurrence and prevalence of MDR-TB in Wuwei City as soon as possible and to formulate a free hospitalization policy for patients with drug-resistant tuberculosis as soon as possible.