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目的 :观察胃舒散、呋喃唑酮和阿莫西林对幽门螺杆菌 (Hp)阳性十二指肠溃疡 (DU)的疗效及根除Hp对溃疡复发的影响。方法 :73例 Hp阳性 DU患者随机分为两组 :三联组 4 1例 ,服用胃舒散 2 .0 g,呋喃唑酮 0 .1g,阿莫西林 0 .5 g,各 3次 /d ,2周后再继服胃舒散 4周。雷尼替丁组 32例 ,服用雷尼替丁 0 .15 g,3次 /d,共 6周。治疗前后均记录胃痛症状 ,内镜观察溃疡情况 ,并进行 2年随访。Hp检测采用 Warthin- Starry银染色法 ,1 4C-尿素呼气试验或快速尿素酶试验 ,2项阳性为 Hp感染 ,阴性为 Hp根除。结果 :6周治疗结束后 ,两组溃疡愈合率均为10 0 %。三联组临床症状缓解率、副反应发生率为 97.6 %和 18.8% ,雷尼替丁组为 93.8%和 9.4 % (均 P >0 .0 5 )。三联组 Hp根除率 (92 .7% )显著高于雷尼替丁组 (0 % ,P <0 .0 1)。 Hp根除的 38例中 ,1年及 2年溃疡复发率为(5 .3% ,10 .5 % )均显著低于 Hp持续感染者 (2 8.1% ,4 6 .9% ,P <0 .0 1)。结论 :以胃舒散为主的三联疗法具有疗效高、副作用少、溃疡复发率低的优点 ,是一种根除 Hp的较好方案。
Objective: To observe the effect of Weishu powder, furazolidone and amoxicillin on Helicobacter pylori (Hp) -positive duodenal ulcer (DU) and the eradication of Hp on the recurrence of ulcer. Methods: Seventy-three patients with Hp-positive DU were randomly divided into two groups: 41 in the triple group, with 2.0 g of Weishuosan, 0.1 g of furazolidone, 0.5 g of amoxicillin, 3 times a day for 2 weeks Followed by stomach Stomach Powder for 4 weeks. Ranitidine group of 32 patients taking ranitidine 0 .15 g, 3 times / d, a total of 6 weeks. Stomach pain symptoms were recorded before and after treatment, ulcers were observed by endoscopy and were followed up for 2 years. Hp test using Warthin-Starry silver staining, 1 4C-urea breath test or rapid urease test, 2 were positive for Hp infection, negative for Hp eradication. Results: After 6 weeks of treatment, the ulcer healing rates in both groups were 100%. The rate of clinical symptom relief was 97.6% and 18.8% in the triple group and 93.8% and 9.4% in the ranitidine group (all P> 0.05). The triple-group Hp eradication rate (92.7%) was significantly higher than the ranitidine group (0%, P <0.01). Among the 38 patients with Hp eradication, the recurrence rates of ulcers at 1 year and 2 years were significantly lower than those with persistent Hp infection (5.21%, 4.6%, P <0.05). 0 1). Conclusion: The triple therapy, which is mainly based on Weishu powder, has the advantages of high curative effect, less side effects and low ulcer recurrence rate. It is a better plan to eradicate Hp.