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醋氨己酸锌（ＺＡＣ）是一种新的治疗消化性溃疡药物。国外研究显示其治疗消化性溃疡的疗效与Ｈ２－受体拮抗剂相似。本研究对８８例消化性溃疡病人随机分成二组：ＺＡＣ治疗组４６例和西米替丁（ＣＭＴ，泰胃美）对照组４２例，观察疼痛及其他消化道症状的缓解率，并经胃镜观察溃疡的愈合情况。结果显示：ＺＡＣ组胃溃疡的愈合率为６１．５４％，总有效率为８４．６２％；十二指肠球部溃疡的愈合率为５４．５５％，总有效率为８４．８５％。ＣＭＴ组胃溃疡愈合率和总有效率分别是５８．３％和７５％，球部溃疡分别为４６．４７％和７６．６７％。两组无显著性差异。两组对疼痛及其他消化道症状的缓解率亦相近，但两组治疗后均能明显降低胃内酸度，具有统计学意义。而血清胃泌素、血清锌及胃液锌浓度无显著性差异。说明ＺＡＣ治疗消化性溃疡可达到Ｈ２－受体拮抗剂同样的效果。
Zinc carbaminate (ZAC) is a new drug for treating peptic ulcer. Foreign studies have shown that the treatment of peptic ulcer efficacy and H2-receptor antagonist. In this study, 88 patients with peptic ulcer were randomly divided into two groups: 46 patients in the ZAC treatment group and 42 patients in the control group (CMT), the pain relief rate and other gastrointestinal symptoms were observed. Observe ulcer healing. The results showed that the healing rate of gastric ulcer in ZAC group was 61.54% and the total effective rate was 84.62%. The healing rate of duodenal ulcer was 54.55% and the total effective rate was 84.85%. The healing rate and total effective rate of gastric ulcer in CMT group were 58.3% and 75% respectively, and the ulceration of ulcer was 46.47% and 76.67% respectively. No significant difference between the two groups. The two groups of pain and other gastrointestinal symptoms remission rate is also similar, but both groups can significantly reduce gastric acidity, with statistical significance. Serum gastrin, serum zinc and gastric zinc concentration was no significant difference. This shows that ZAC treatment of peptic ulcer can reach the same effect of H2-receptor antagonist.