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目的探讨血管抑素(AS)与膜联蛋白AnnexinⅡ在血管瘤与血管畸形中的表达及意义。方法采用Realtime-qPCR方法检测毛细血管瘤、海绵状血管瘤、蔓状血管瘤中AnnexinⅡ与AS的表达水平,以正常皮肤组织作对照。结果毛细血管瘤组AS,AnnexinⅡ的表达水平分别是正常皮肤组织的2.39和1.76倍。其他各组AS的表达略低于正常对照组,血管瘤与血管畸形中AnnexinⅡ的表达差异无统计学意义。结论 AS可能参与血管瘤发生过程,AnnexinⅡ在各种血管性皮肤病中作用无特异性,AS抑制血管增生的作用可能由多种途径介导。
Objective To investigate the expression and significance of angiostatin (AS) and annexin Ⅱ in hemangiomas and vascular malformations. Methods Realtime-qPCR was used to detect the expression of Annexin Ⅱ and AS in capillary hemangiomas, cavernous hemangiomas and hemangiomas. Normal skin tissues were used as controls. Results The expression of AS and AnnexinⅡ in capillaries was 2.39 and 1.76 times higher than normal skin tissues, respectively. The expression of AS in other groups was slightly lower than that in normal control group, and there was no significant difference in the expression of Annexin Ⅱ between hemangiomas and vascular malformations. Conclusion AS may be involved in the process of hemangiomas. Annexin Ⅱ has no specific effect on various vascular dermatoses. AS may be mediated by a variety of pathways.