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先兆子痫以血管痉挛和内皮损害为特征。发病原因仍不清楚。为确定溶血、肝酶升高及血小板减少(HELLP)综合征患者中是否释放巨噬细胞产生的细胞因子:白介索(IL)-1β、IL-6和肿瘤坏死因子(TNF)-α以及C5a(一种白细胞趋化因子)是否诱导这些细胞因子的分泌,11例HELLP综合征妇女和11例无妊娠合并症者进行对照研究。两组均于分娩时、产后24小时和7天收集血标本,研究补体的激活和细胞因子在血浆中的水平。并进行了将肝素化
Pre-eclampsia is characterized by vasospasm and endothelial damage. The cause of the disease is still not clear. To determine whether cytokines produced by macrophages are released from patients with hemolysis, elevated liver enzymes, and thrombocytopenia (HELLP) syndromes: interleukin-1β, IL-6 and tumor necrosis factor (TNF) -α and Whether C5a (a leukocyte chemokine) induces the secretion of these cytokines, a control study was performed in 11 HELLP syndrome women and 11 non-pregnancy complications. Blood samples were collected at childbirth, 24 hours and 7 days after childbirth to investigate the activation of complement and the level of cytokines in plasma. Heparinization was performed