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目的:研究雷公藤多苷与肝素在紫癜性肾炎患儿中的联合应用。方法:将52例紫癜性肾炎患儿分为两组,分别是治疗组和对照组,各为26例。对照组进行常规治疗,低盐和优质蛋白饮食,控制血压、维持水和电解质的平衡。治疗组在对照组治疗的基础上,每天口服雷公藤多苷,注射肝素。疗程持续8周。结果:全部儿童患者均可以接受雷公藤多苷和肝素治疗,并且治愈率高,不易复发。服用雷公藤多苷一段时间后,会出现白细胞减少,减量服用或停用一段时间,白细胞恢复正常。患儿肝酶会有微量升高,不超过100u/L。结论:雷公藤多苷和肝素在治疗紫癜性肾炎患儿中有显著疗效,有效降低尿蛋白、肌酐和尿素氮,值得临床推广应用。
Objective: To study the combined application of tripterygium glycosides and heparin in children with purpura nephritis. Methods: Fifty-two children with purpuric nephritis were divided into two groups: treatment group and control group, with 26 cases in each. The control group was treated routinely with low-salt and high-quality protein diet to control blood pressure and maintain water and electrolyte balance. Treatment group in the control group based on the treatment, oral administration of tripterygium glycosides, heparin injection. The course of treatment lasts 8 weeks. Results: All pediatric patients were treated with tripterygium glycosides and heparin, and the cure rate was high, not easy to relapse. After taking Tripterygium glycosides for a period of time, there will be leukopenia, reduced-dose or disabled for some time, white blood cells returned to normal. Liver enzymes in children will have a slight increase, no more than 100u / L. Conclusion: Tripterygium glycosides and heparin in the treatment of children with purpura nephritis have a significant effect, effectively reducing urinary protein, creatinine and urea nitrogen, worthy of clinical application.