论文部分内容阅读
目的观察早期乳腺癌保乳术后常规放疗的美容效果及较远期疗效。方法进入研究的条件为单一病灶,肿块最大直径≤3 cm,显微镜下手术切缘阴性,腋窝淋巴结清扫为阴性。排除炎性乳腺癌和男性乳腺癌。42例0、Ⅰ、Ⅱ期乳腺癌保乳手术后使用6 MV X线切线野常规分割照射,全乳房照射50 Gy,局部瘤床区电子线补量照射10 Gy。治疗后2年内每3个月、第3-5年每6个月、之后每年随访1次,观察治疗和美容效果。结果全组病例随访19-90个月(中位随访56个月),2例分别在治疗后16、36个月因远处转移死亡,CT确诊。美容效果和患者满意度均超过93%。无一局部复发,局部控制率100%。1、3年生存率分别为100%、98%。结论早期乳腺癌保乳术后6 MV X线切线野照射疗效可靠、美容效果良好且急性和晚期毒性作用小,因此更有利于早期乳腺癌患者生活质量的提高。
Objective To observe the cosmetic effect and the long-term effect of conventional radiotherapy after breast-conserving surgery in early breast cancer. Methods The conditions for entry into the study were a single lesion with a maximum mass diameter of ≤3 cm, a negative surgical margin under the microscope and a negative axillary lymph node dissection. Exclude inflammatory breast cancer and male breast cancer. Forty-two patients with stage 0, stage I and stage II breast-conserving surgery were routinely irradiated with a 6-MV X-ray line, 50 Gy in the whole breast and 10 Gy in the local tumor bed. Every 3 months after 2 years of treatment and every 6 months during the 3rd to 5th years after treatment, the patients were followed up once a year to observe the therapeutic and cosmetic effects. Results All patients were followed up for 19-90 months (median follow-up 56 months). Two patients died of distant metastasis at 16 and 36 months after treatment, respectively. CT was confirmed. Beauty and patient satisfaction were more than 93%. No local recurrence, local control rate of 100%. 1, 3-year survival rates were 100%, 98%. Conclusions The 6-MV X-ray tangent field irradiation after breast-conserving surgery is reliable, the cosmetic effect is good, and the acute and late toxic effects are small, so it is more conducive to the improvement of quality of life in patients with early-stage breast cancer.