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本实验为对比血管内皮生长因子(vascular endothelialgrowth factor,VEGF)与微血管密度(micoreesel densig,MND)在不同病理分型,WHO分级的膀胱肿瘤中的表达差异及其意义.通过应用免疫组化方法研究了膀胱移行细胞癌、鳞状细胞癌和腺癌的VEGF表达及MND.由于后两种癌发病率低,按临床分期或分级收集标本困难.本实验为移行细胞癌进行了WHO分级,并分别与鳞状细胞癌和腺癌的实验结果进行了比较.其结果是VEGF蛋白在正常膀胱组织中不表达,在膀胱癌组织中呈高表达.随着病理级别增高VEGF表达水平与肿瘤恶性程度呈正相关.用Ⅲ级移行细胞癌与中低分化的鳞状细胞癌和腺癌的VEGF阳性率进行比较,统计学上无明显差异.提示肿瘤细胞VEGF表达与病理组织类型无关,而与肿瘤细胞的分化程度有关.本研究发现MND与膀胱癌分级显著相关(P<0.05)且与VEGF呈正相关.我们
This study compared the expression of VEGF and MND in different pathological types and WHO grade bladder tumors and its significance.According to the study of immunohistochemistry The expression of VEGF and MND in bladder transitional cell carcinoma, squamous cell carcinoma and adenocarcinoma is difficult to collect by clinical staging or grading because of low incidence of the latter two types of cancer.This experiment was performed for WHO classification of transitional cell carcinoma and respectively And squamous cell carcinoma and adenocarcinoma experimental results were compared.As a result, VEGF protein in normal bladder tissue is not expressed in bladder cancer tissue was highly expressed.With the pathological grade increased VEGF expression levels and tumor malignancy was positive Correlation between grade Ⅲ transitional cell carcinoma and moderately poorly differentiated squamous cell carcinoma and adenocarcinoma of VEGF positive rate compared with statistically no significant difference.It suggests that the expression of VEGF in tumor cells has nothing to do with the type of pathological tissue, The degree of differentiation.This study found that MND was significantly correlated with the grade of bladder cancer (P <0.05) and positively correlated with VEGF