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目的：了解５／６肾切除大鼠尿纤溶酶原激活物（ＰＡ）排泄量的动态变化。方法：５／６肾切除术后不同时间点分别检测尿ＰＡ活性以及血、尿生化指标，并进行肾脏光镜、电镜检查。结果：术后２周血肌酐显著升高但肾脏病理改变轻微，多数大鼠尿ＰＡ排泄量仍能维持正常水平。术后４周以肾小球肥大和系膜增殖改变为特征，血肌酐正常；部分大鼠尿ＰＡ排泄量减少，也有部分大鼠尿ＰＡ排泄量增加。术后６～８周肾功能失代偿，尿蛋白大量排出，肾脏病理以肾小球局灶节段硬化、新月体形成、纤维素样渗出，以及肾小管－间质病变为特征。此期尿ＰＡ排泄量逐渐增高，８周时２４ｈ尿ＰＡ排泄量显著高于假手术组。结论：５／６肾切除术后，残余肾脏排泄ＰＡ逐渐增加。
Objective: To investigate the dynamic changes of urinary plasminogen activator (PA) excretion in 5/6 nephrectomized rats. Methods: The urinary PA activity, blood and urine biochemical indexes were detected at different time points after 5/6 nephrectomy. The kidneys were examined by light microscope and electron microscope. Results: Serum creatinine was significantly increased 2 weeks after operation, but renal pathological changes were mild. Urinary PA excretion in most rats remained normal. 4 weeks after the glomerular hypertrophy and mesangial proliferation was characterized by changes in serum creatinine normal; part of rats decreased urinary PA excretion, but also some rats increased urinary PA excretion. 6 to 8 weeks after renal decompensation, urinary protein excretion, renal pathology with focal segmental sclerosis, crescent formation, fibrin-like exudate, and tubulointerstitial lesions were characterized. During this period, the urinary PA excretion increased gradually, and the urinary PA excretion in 24h urine was significantly higher than that of the sham operation group at 8 weeks. Conclusion: After 5/6 nephrectomy, PA excretion in residual kidneys gradually increased.