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设计并合成了含手性侧基和含亲水性大分子侧基的接枝聚炔共聚物[聚(丙炔酸薄荷醇酯-co-丙炔酸聚乙二醇单甲醚酯)(poly(a-co-b),(a:propiolic acid L-menthol ester;b:propiolic acid polyethylene glycolmonomethyl ether ester)).通过比旋光度([α]D),圆二色光谱(CD)表征手段发现共聚物poly(a-co-b)具有很强的光学活性且能形成单一方向的螺旋构象.另外还考察了共聚物中聚乙二醇单甲醚(MPEG)含量、溶剂极性及时间对共聚物的光学活性和二级结构的影响,结果表明,随着MPEG含量的增加,共聚物的光学活性会降低.在所选的4种溶剂中(三氯甲烷,四氢呋喃,二氯甲烷,苯),共聚物的螺旋构象在三氯甲烷溶剂中最能稳定存在.然而此类共聚物的二级结构在溶剂中是不稳定的,其光学活性会随着时间的延长而逐渐减弱.
Design and synthesis of graft poly (acetylene) copolymers containing chiral pendant groups and pendant hydrophilic groups [poly (menthyl propiolate-co-propiolate polyethylene glycol monomethyl ether acetate) (a: propiolic acid polyethylene glycol monomethyl ether ester)). By specific rotation ([α] D), circular dichroism (CD) characterization means It was found that the copolymer poly (a-co-b) has a strong optical activity and can form a single direction helical conformation.In addition, the polyethylene glycol monomethyl ether (MPEG) content, solvent polarity and time On the optical activity and the secondary structure of the copolymer.The results showed that the optical activity of the copolymer decreased with the increase of MPEG content.In the four selected solvents (chloroform, tetrahydrofuran, methylene chloride, Benzene), the helical conformation of the copolymer is the most stable among the chloroform solvents.However, the secondary structure of these copolymers is unstable in the solvent, and its optical activity will be weakened with time.