Bee Venom Acupuncture Induced Skin Patch Discoloration Persisting for More than 3 Years:A Case Repor

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Bee venom (BV),one of the most commonly encountered types of animal venom,consists of a mixture of chemical agents that cause allergic reactions in the human body.(1) BV therapy,in which BV is exploited for medicinal purposes,is available worldwide,mainly used in Asia,Eastern Europe,and South America.(2) BV therapy has been applied to treat a diverse set of diseases including various musculoskeletal conditions such as arthritis and rheumatism,arthralgia,chronic recalcitrant neuralgia,(3-5) Parkinson\'s disease,(6,7) postherpetic neuralgia,(8) and morphea.(9) Although the therapeutic utility of BV has been demonstrated,extensive studies regarding the safety of BV as a therapeutic agent have identified potential side effects,ranging from minor skin reactions that typically resolve over several days to severe life-threatening immune responses such as anaphylaxis.
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