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目的 评价胺碘酮预防冠状动脉旁路移植术术后心房颤动的有效性.方法 计算机检索中国生物医学文献数据库(CBM,1978年1月～2017年8月)、中国学术期刊全文数据库(CNKI,1987年1月～ 2017年8月)、维普数据库(VIP,1989年1月~2017年8月)、万方数据库(1998年1月~2017年8月)及PubMed数据库(1989年1月~2017年8月).按纳入及排除标准进行文献筛选,并提取资料.用改良的Jadad量表评价文献质量.采用Cochrane协作网提供的RevMan5.3进行Meta分析.结果 共纳入19篇文献,均为随机对照试验,共2817例患者.Jadad评分高质量文献16篇,低质量3篇.Meta分析显示:与安慰剂组(对照组)相比,胺碘酮(试验组)降低冠状动脉旁路移植术术后心房颤动的发生率[RR=0.37, 95％ CI(0.28, 0.50),P<0.000 01].亚组分析:与安慰剂组(对照组)相比,胺碘酮不同给药时间及给药方式对动脉旁路移植术术后心房颤动有显著影响(P<0.05) .结论 与安慰剂相比,胺碘酮有效地降低冠状动脉旁路移植术术后心房颤动的发生率.“,”Objective To evaluate efficacy of amiodarone in the prevention of atrial fibrillation after coronary artery bypass grafting. Methods CBM (from January 1978 to August 2017), CNKI (from January 1987 to August 2017), VIP (from January 1989 to August 2017), Wanfang (from January 1998 to August 2017) and PubMed (from January 1989 to August 2017) databases were searched. The articles were selected based on the inclusion and exclusion criteria. Quality of articles was assessed by improved Jadad scale. Statistical analysis was performed using RevMan 5.3. Results There were 19 articles meeting inclusion criteria including 2 817 patients and all were randomized controlled trial (RCT). There were 16 articles with high quality and 3 articles with low quality by improved Jadad scale. Compared with the placebo, amiodarone had a significant effect on reducing the incidence of atrial fibrillation after coronary artery bypass grafting (RR=0.37, 95％ CI 0.28 to 0.50, P<0.000 01) and different administration models and time of amiodarone had effect on the atrial fibrillation after aterial bypass grafting (P<0.05). Conclusion Compared with the placebo, amiodarone is effective in reducing the incidence of atrial fibrillation after coronary artery bypass grafting.