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作者研究了尼索地平(Nisoldipine)对心衰患者血流动力学及左室收缩性能的急性作用。 10例缺血性心脏病伴心力衰竭的患者,常规药治疗2～3周,并停用钙通道阻滞剂。然后静滴尼索地平,每分钟0.12/μg/kg。静滴尼索地平过程中,平均动脉压由89±14降为73±7mmHg(P=0.001),体循环血管阻力由1285±177降为1064±253dyn·s·cm~(-5)(P<0.02),心脏指数由每分钟2.8±0.2增至3.0±0.4 L/m~2(无统计学意义),每搏指数由32±5增至35±7ml/m~2
The authors studied the acute effects of Nisoldipine on hemodynamics and left ventricular systolic performance in patients with heart failure. 10 patients with ischemic heart disease with heart failure, conventional treatment for 2 to 3 weeks, and disable calcium channel blockers. Nisoldipine was then intravenously administered at 0.12 / μg / kg per minute. Mean arterial pressure decreased from 89 ± 14 to 73 ± 7 mmHg (P = 0.001) and systemic vascular resistance decreased from 1285 ± 177 to 1064 ± 253 dyn · s · cm -5 (P < 0.02). The cardiac index increased from 2.8 ± 0.2 per minute to 3.0 ± 0.4 L / m ~ 2 (no statistical significance). The stroke index increased from 32 ± 5 to 35 ± 7ml / m ~ 2