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目的:研究老年男性血清脂联素与骨密度和骨转化指标之间的关系。方法:对165例男性老年患者采用双能量X线吸收测量仪测定骨密度、肌肉及脂肪量,同时测定患者血清脂联素、骨碱性磷酸酶、甲状旁腺素、25羟维生素D和I型胶原β羧基端肽水平。结果:165例年龄超过58岁男性患者(平均年龄69.4±6.4岁,体重指数24.9±3.1 kg/m2),脂联素与股骨颈骨密度相关系数为-0.31(P<0.05)、与全髋骨密度相关系数为-0.23(P<0.05),年龄、BMI和脂肪量校正后,脂联素仅与股骨颈骨密度有显著相关(r=-0.25,P<0.05);脂联素与骨碱性磷酸酶正相关(r=0.28,P<0.01),混杂因素校正后,相关仍具有显著性(r=0.19,P<0.05);脂联素与I型胶原β羧基端肽呈正相关(r=0.15,P<0.05)。结论:老年男性血清脂联素与股骨颈骨密度和骨ALP密切相关。
Objective: To study the relationship between serum adiponectin and bone mineral density and bone turnover in elderly men. Methods: Bone mineral density (BMD), muscle mass and fat mass were measured by dual energy X-ray absorptiometry in 165 male aged patients. Serum levels of adiponectin, bone alkaline phosphatase, parathyroid hormone, 25-hydroxyvitamin D and I Collagen β carboxy-terminal peptide levels. Results: A total of 165 male patients over the age of 58 (mean age 69.4 ± 6.4 years, body mass index 24.9 ± 3.1 kg / m2) had a correlation coefficient of -0.31 (P <0.05) with total hip The correlation coefficient of BMD was -0.23 (P <0.05). After adjusting for age, BMI and fat mass, adiponectin only had significant correlation with femoral neck BMD (r = -0.25, P <0.05) Alkaline phosphatase (r = 0.28, P <0.01). Correlation was still significant (r = 0.19, P <0.05) after the confounding factors were corrected. Adiponectin was positively correlated with beta-carboxy terminal peptide of type I collagen r = 0.15, P <0.05). Conclusion: Serum adiponectin in elderly men is closely related to bone mineral density and bone ALP.