目的观察不同程度的全身炎症反应综合征(SIRS)患儿的C-反应蛋白(CRP)、降钙素原、D-二聚体及抗AT-Ⅲ浓度水平,探讨其变化与SIRS病情的关系。方法 90例SIRS患儿按SIRS符合项数分为三组,每组30例,选择同期体检正常儿童28例为对照组,记录基本信息,并对所有入选对象进行CRP、降钙素原、D-二聚体及抗AT-Ⅲ浓度检测。结果随着SIRS符合项数的增加,CRP、降钙素原上升,差异有统计学意义(H=81.24/77.64,P均<0.01);随着SIRS符合项数的增加,D-二聚体上升,抗凝血酶Ⅲ活性减低,差异有统计学意义(F=316.61/128.03,P<0.01),两两比较差异均有统计学意义,P<0.01。结论 SIRS患儿合并有凝血功能紊乱,炎症反应越重,凝血功能紊乱越明显。 Objective To observe the levels of C-reactive protein (CRP), procalcitonin, D-dimer and anti-AT-Ⅲ in children with systemic inflammatory response syndrome (SIRS) to investigate the relationship between the changes and the severity of SIRS . Methods 90 SIRS infants were divided into three groups according to the SIRS coincidence number, 30 cases in each group. 28 normal children were selected as the control group in the same period, and the basic information was recorded. All subjects were selected for CRP, procalcitonin, D - dimer and anti-AT-Ⅲ concentration test. Results The CRP and procalcitonin increased with the increase of SIRS coincidence number (H = 81.24 / 77.64, P <0.01). With the increase of SIRS coincidence number, D-dimer (F = 316.61 / 128.03, P <0.01). There was significant difference between any two groups (P <0.01). Conclusion SIRS children with coagulation disorders, the more severe inflammatory reactions, the more obvious coagulation disorders.