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对基因重组干扰素γ（ＩＦＮ－γ）体外对３２例骨髓增生异常综合征（ＭＤＳ）患者造血祖细胞的作用进行了研究，结果如下：①ＭＤＳ患者ＣＦＵ－Ｅ和ＣＦＵ－ＧＭ明显低于对照组，ＣＦＵ－Ｅ减低者占３０／３２例，ＣＦＵ－ＧＭ减低者占３１／３２例。②ＩＦＮ－γ体外可促进ＣＦＵ－Ｅ和ＣＦＵ－ＧＭ数增加，其作用为剂量依赖型，在ＩＦＮ－γ浓度为１００Ｕ／ｍｌ时达最大值。③ＩＦＮ－γ对ＭＤＳ患者ＣＦＵ－Ｅ和ＣＦＵ－ＧＭ的促增殖作用与患者自身集落数有关，在自身集落数正常和稍减低者这种作用最明显，在明显减低者这种作用小甚至为０．④上海和日本二种干扰素作用相似，无显著差异。以上结果提示ＩＦＮ－γ对ＭＤＳ治疗可望产生良好效果。
The effects of IFN-γ on hematopoietic progenitor cells in 32 patients with myelodysplastic syndrome (MDS) were studied in this paper. The results were as follows: ① The CFU-E and CFU-GM in patients with MDS were significantly lower than those in control group , CFU-E reduction accounted for 30/32 cases, CFU-GM reduction accounted for 31/32 cases. ② In vitro, IFN-γ promoted the increase of CFU-E and CFU-GM, and its effect was dose-dependent, reaching its maximum at IFN-γ concentration of 100 U / ml. (3) The effect of IFN-γ on the proliferation of CFU-E and CFU-GM in MDS patients was related to the number of patients themselves. The effect of IFN-γ on CFU-E and CFU-GM was the most obvious in patients with normal and slight decrease of their own numbers. . ④Shanghai and Japan two kinds of interferon effect is similar, no significant difference. The above results suggest that IFN-γ is expected to have a good effect on MDS treatment.