丝切蛋白(cofilin)为肌动蛋白分子结合蛋白,通过其特定的上、下游信号转导通路在神经元轴突、树突及树突棘的迁移、定位、生长、改造出新棘突等过程中发挥着重要的调控作用,参与神经突触可塑性调节,特别是Rho GTPases家族Rho、Rac和Cdc42是cofilin基因上游重要的调控分子,通过介导突触重塑,与缺血缺氧性脑损伤、癫痫、帕金森病、阿尔茨海默病、学习记 Cofilin is an actin molecule-binding protein that transforms, locates, and grows axonal, dendritic and dendritic spines in neurons through its specific upstream and downstream signaling pathways Plays an important role in the regulation and regulation of synaptic plasticity, especially the Rho GTPases family Rho, Rac and Cdc42 are important cofilin upstream regulatory molecules, through the mediation of synaptic remodeling, and hypoxic-ischemic brain Injuries, epilepsy, Parkinson’s disease, Alzheimer’s disease, learning notes