异种移植是解决供体移植器官缺乏的较好途径之一 ,但移植后的超急性、急性以及后续的各种免疫排斥反应限制了它的临床应用。目前关于异种移植排斥反应机制和种间耐受的研究非常活跃 ,本文从组织相容性抗原 (MHC )的抗原特性、T细胞发育识别及NK细胞效应等几方面对MHC在异种移植中作用的进展做了简要综述。 Xenotransplantation is one of the best ways to solve the problem of donor organ transplantation. However, hyperacute, acute and subsequent immune rejection after transplantation limit its clinical application. At present, the research on the mechanism of xenotransplantation rejection and interspecies tolerance is very active. In this paper, the role of MHC in xenotransplantation is studied from the aspect of antigenic character of histocompatibility antigen (MHC), recognition of T cell development and NK cell effect A brief overview of progress.