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目的 研究一氧化氮 (NO)在帕金森病 (PD)大鼠模型神经损伤中的作用。方法 用高效液相色谱电化学法 (HPL C- ET)及还原型辅酶 (NADPH)黄递酶组化法观察 NO在 PD大鼠模型神经损伤中的作用。结果 神经型一氧化氮合成酶 (n NOS)抑制剂 7-硝基吲唑 (7- NI)明显减少 6 -羟基多巴胺 (6 - OHDA )引起的纹状体多巴胺及其代谢产物的降低 (P<0 .0 1) ;纹状体 NADPH黄递酶阳性神经元可抵抗 6 - OHDA的损伤。结论 来源于神经元的 NO参与了 PD大鼠模型的神经损伤过程。
Objective To study the role of nitric oxide (NO) in the neuronal damage of Parkinson’s disease (PD) rats. Methods The effect of nitric oxide (NO) on nerve injury in PD rat model was observed by HPL C-ET and NADPH diaphorase histochemistry. Results The neuronal nitric oxide synthase (nNOS) inhibitor 7 - nitroindazole (7 - NI) significantly reduced the decrease of striatum dopamine and its metabolites induced by 6 - hydroxydopamine (P <0.01). Striatum NADPH diaphorase-positive neurons resist 6-OHDA injury. Conclusion NO derived from neurons is involved in the process of nerve injury in PD rats.