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目的:探讨在OSAHS患者围手术期应用西吡氯铵含片对患者术后控制口咽局部炎症反应的作用。方法:选取确诊为OSAHS的患者60例,按照1:1的比例随机分为治疗组和对照组,采用随机单盲对照试验。治疗组给予西吡氯铵含片治疗,对照组不用,所有患者均行UPPP。比较两组患者术后1d、3d、5d口咽部疼痛情况、口咽部水肿情况、以及唾液中IL-1β、IL-8和TNF-α浓度。结果:试验组术后3d、5d的口咽部疼痛情况明显轻于对照组(P<0.05);试验组术后3d、5d唾液中的IL-1β、IL-8和TNF-α明显低于对照组(P<0.05)。结论:在UPPP术围手术期使用西吡氯铵含片能改善患者术后咽痛,改善口咽局部炎症反应,降低炎症因子的表达。
OBJECTIVE: To investigate the effect of ciclopirox olamine in the perioperative management of OSAHS patients on the local control of oropharyngeal inflammatory response. Methods: Sixty patients diagnosed as OSAHS were selected and randomly divided into treatment group and control group according to the ratio of 1: 1. Randomized single-blind controlled trials were conducted. The treatment group was given cetylpyridinium chloride tablets, the control group did not, all patients underwent UPPP. The postoperative 1d, 3d, 5d oropharyngeal pain, oropharyngeal edema, as well as the concentrations of IL-1β, IL-8 and TNF-α in saliva were compared between the two groups. Results: The pain of the oropharyngeal of the experimental group was significantly lower than that of the control group (P <0.05) 3d and 5d after operation. The levels of IL-1β, IL-8 and TNF-α in saliva of the experimental group were significantly lower than those of the control group Control group (P <0.05). Conclusion: The use of cetylpyridinium chloride perioperative period in UPPP can improve postoperative sore throat, improve the local inflammation of the oropharynx and reduce the expression of inflammatory cytokines.