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本文报道良性子宫内膜组织与妇科恶性肿瘤共203例的胞液雌激素受体(ER)及孕激素受体(PR)的测定结果,测定方法采用DCC法。除了卵巢癌及外阴癌外PR值高于ER值。良性子宫内膜包括正常子宫内膜、内膜息肉及子宫内膜增生过长的PR值及ER值皆高于子宫内膜癌及其他妇科肿瘤。PR值在妇科恶性肿瘤中是以子宫内膜癌最高,宫颈癌次之,阴道癌,卵巢癌、外阴癌依次递减。而ER则以子宫内膜癌、卵巢癌、阴道癌、宫颈癌及外阴癌递减。子宫内膜癌生存<1年者PR及ER明显降低,与良性子宫内膜比较有显著差异(P<0.01)。本资料说明PR及ER对提示妇科恶性肿瘤有一定价值,尤其是对子宫内膜癌的预后及治疗有一定参考价值。
This article reports 203 cases of benign endometrial cancer and gynecological malignancies cytosolic estrogen receptor (ER) and progesterone receptor (PR) determination results measured by DCC method. In addition to ovarian cancer and vulvar cancer PR value higher than the ER value. The benign endometrium, including normal endometrium, endometrial polyps and endometrial hyperplasia PR and ER values are higher than the endometrial cancer and other gynecological tumors. PR value in gynecological malignancies is the highest endometrial cancer, followed by cervical cancer, vaginal cancer, ovarian cancer, vulvar cancer, followed by decreasing. The ER is endometrial cancer, ovarian cancer, vaginal cancer, cervical cancer and vulvar cancer decreased. PR and ER were significantly lower in patients with endometrial cancer <1 year, which was significantly different from that in benign endometrium (P <0.01). This information shows that PR and ER on gynecological malignancies have some value, especially for the prognosis and treatment of endometrial cancer have some reference value.