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目的：观察山药对糖尿病小鼠组织丙二醛（ ＭＤＡ） 含量的影响。方法：采用四氧嘧啶制作糖尿病小鼠模型，并以优降糖作阳性对照，连续２１ 天用不同剂量山药灌胃治疗，比较各组心脏、肝脏、肾脏和胰脏过氧化脂质的终末代谢产物ＭＤＡ 含量。结果：①对照组四器官ＭＤＡ显著高于正常组（Ｐ＜ ０ ．０１ 或Ｐ＜ ０ ．００１） ；②剂量在６ ．００ｇ／ｋｇ·ｄ－ １ 以上山药各治疗组四器官ＭＤＡ显著低于对照组（Ｐ＜ ０ ．０５ 或Ｐ＜ ０．００１） ；③与优降糖组比，除肝脏ＭＤＡ 较高外（Ｐ＜ ０．００１） ，中、大剂量山药组心、胰、肾组织ＭＤＡ 较低（Ｐ＜ ０ ．０５ 或Ｐ＜ ０ ．００１） 。结论：山药能明显降低糖尿病小鼠组织内过氧化脂质含量，尤其对心组织作用最强，其次为胰、肾和肝组织，而优降糖对胰组织过氧化脂质无明显影响。
Objective: To observe the effect of yam on the content of malondialdehyde (MDA) in diabetic mice. METHODS: Diabetic mice models were made using alloxan, and glibenclamide was used as a positive control. The rats were treated with different doses of yam for 21 consecutive days. The lipid peroxidation of the hearts, livers, kidneys, and pancreas in each group was compared. Metabolite MDA content. RESULTS: 1 The MDA in the four organs of the control group was significantly higher than that in the normal group (P < 0. 01 or P <0.001); The MDA in the four organs of the yam treatment groups above 00g/kg·d-1 was significantly lower than that of the control group (P<0.05 or P<0.001); 3 was higher than that of the glibenclamide group, except for the higher MDA in the liver (P <0.001), MDA in the heart, pancreas and kidney tissues of middle- and high-dose yams group was lower (P < 0. 05 or P <0. 001). Conclusion: Yam can significantly reduce the content of lipid peroxide in diabetic mice, especially the heart tissue, followed by the pancreas, kidney and liver tissue. However, glibenclamide has no significant effect on lipid peroxides in pancreatic tissue.