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设计合成了一系列基于脯氨酸巯基咪唑衍生物的新型双亲性有机小分子催化剂,在水相中加入酸作为助催化剂,可以高效高选择性的催化环己酮与硝基烯烃的不对称Michael加成反应,非对映选择性和对映选择性分别高达99:1和96%.
A series of novel amphiphilic organic small molecule catalysts based on proline mercaptoimidazole derivatives were designed and synthesized. The addition of acid as a cocatalyst in the aqueous phase catalyzed the asymmetric Michael reaction between cyclohexanone and nitroalkene efficiently and selectively Addition reaction, diastereoselectivity and enantioselectivity were as high as 99: 1 and 96%.