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目的 :探讨有脑血管病家族史的脑梗死患者与其子女血清脂蛋白 (α)浓度的相关性及临床意义 .方法 :检测有明确脑血管病家族史的 2 16例脑梗死患者及其子女的血清脂蛋白 (α)浓度 ,并与 46例正常人及其子女血清脂蛋白 (α)的浓度进行比较。结果 :正常对照组亲、子代以及脑梗死患者亲、子代血清脂蛋白 (α)的相关系数 (r)均为 0 .6 8,P均 <0 .0 0 0 1,显示二者均具有非常显著的相关性。与正常对照组亲、子代相比 ,脑梗死组亲、子代血清脂蛋白 (α)浓度〔分别为 (5 5 0 .0± 341.1) mg/L和 (4 2 2 .9± 30 4.2 ) mg/L〕均显著高于正常对照组亲、子代〔分别为 (2 15 .9± 135 .7) mg/L 和 (144 .6± 10 6 .9) mg/L,P均 <0 .0 0 0 1〕。脑梗死合并糖尿病和高血压者与单纯脑梗死相比 ,其血清脂蛋白 (α)浓度无显著差异 (P均 >0 .0 5 ) ,但脑梗死合并冠心病者其血清脂蛋白 (α)浓度比脑梗死不伴冠心病者显著升高〔分别为 (5 84.7± 345 .3) m g/L 和 (4 6 5 .6± 32 1.4) mg/L,P<0 .0 1〕。结论 :血清脂蛋白 (α)浓度具有显著的遗传特性 ,是脑梗死患者的独立危险因素之一 ,其血清浓度代表动脉粥样硬化的严重程度 ,有脑血管病家族史患者的子女检测血清脂蛋白 (α)浓度 ,对其及早预防脑梗死发生有重要的意义
Objective: To investigate the correlation and clinical significance of serum lipoprotein (α) in patients with a family history of cerebrovascular disease and their children.Methods: Twenty-six patients with a family history of cerebrovascular disease and their children Serum lipoprotein (α) concentrations were compared with those of 46 normal subjects and their children. Results: The correlation coefficients (r) of serum lipoprotein (α) in pro and pro offspring of the progeny, offspring and patients with cerebral infarction were both 0.68, P <0.01, which showed that both Has a very significant correlation. Compared with the progeny and offspring in the normal control group, the levels of serum lipoprotein (α) in the progeny and offspring of the cerebral infarction group were (550 ± 341.1) mg / L and (42.29 ± 30 4.2 ) mg / L] were significantly higher than that of the normal control group [(21.15 ± 135.7) mg / L and (144.6 ± 106.9) mg / L, respectively, P < 0 .0 0 0 1]. Compared with simple cerebral infarction, there was no significant difference in serum lipoprotein (α) concentrations between cerebral infarction with diabetes mellitus and hypertension with cerebral infarction (all P0.05), but serum lipoprotein (α) Concentrations were significantly higher than those without coronary heart disease in cerebral infarction (5 84.7 ± 345.3 mg / L and (466 ± 32 1.4) mg / L, P <0.01, respectively]. Conclusion: Serum lipoprotein (α) concentration has significant genetic characteristics and is an independent risk factor for patients with cerebral infarction. The serum concentration of atherosclerosis represents the severity of atherosclerosis. Serum lipids levels are detected in children with a family history of cerebrovascular disease Protein (α) concentration, its early prevention of cerebral infarction is of great significance