氟哌酸(诺氟沙星)为氟喹诺酮类抗菌药中开发和应用较早的一种药物。由于其抗菌活性高、杀菌作用快、口服吸收好等优点,国内外临床应用较为普遍。在胶囊剂的生产过程中,由于氟哌酸原料具有较强的吸湿性,以淀粉、糊精作赋形剂、用淀粉浆制粒时因局部吸收水分过快过多,所制软材干湿不均,结块较多,整粒时有部份粘结颗粒难以通过 Norfloxacin (norfloxacin) is a fluoroquinolone antibacterial drug development and application of an earlier drug. Because of its high antibacterial activity, bactericidal effect, good oral absorption, clinical application at home and abroad are more common. In the capsule production process, due to the raw material of norfloxacin with strong hygroscopicity, with starch, dextrin as excipients, when using starch slurry granulation due to local absorption of water too fast too much, the system made of wet and dry Uneven, more agglomeration, when the whole part of the bonding particles are difficult to pass