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1979年 Kaplan 等报道86例革兰氏阴性菌败血症中,20例发生 ARDS。此征预后极差,死亡率可达90%。另报道16例伴 ARDS者,11例血小板减少,提示血小板参予 ARDS 的发病.最近,Kaplan 等在用体外膜肺氧合作用(EMCO)治疗 ARDS 90例中,败血症所致者59例,促发败血症的多数为病毒而不是细菌。另一组490例 ARDS 中,败血症所致者184例,占38%。Kaplan 等认为低氧血症的严重性与持续时间,以及对治疗的反应.特别是对呼气末期正压呼吸(PEEP)的反应与预后有关。Lamy 等报道,用100%的氧气,当动脉氧分压为150torr 时,21例对 PEEP 反应良好,死亡率为52%,而当氧分压低于70torr 时,24例对 PEEP 反应差或无反应,死亡率为80%。另外,死亡率增加的原因,除 ARDS 外,还有败血症本身的问题及心功能失调。年龄也是一个重要因素,20岁以下年龄组死亡率为50%,65岁以上增至81%。
1979 Kaplan et al reported 86 cases of Gram-negative sepsis, 20 cases of ARDS. This sign of poor prognosis, the mortality rate of up to 90%. Another reported 16 cases with ARDS, 11 cases of thrombocytopenia, suggesting platelet involvement in the pathogenesis of ARDS.Recently, Kaplan et al in the use of extracorporeal membrane oxygenation (EMCO) treatment of 90 cases of ARDS, sepsis caused by 59 cases of The majority of septicemia virus rather than bacteria. Another 490 cases of ARDS, sepsis caused by 184 cases, accounting for 38%. The severity and duration of hypoxemia, as well as the response to treatment, are believed by Kaplan et al. In particular, the response to positive end expiratory pressure (PEEP) is prognostic. Lamy et al. Reported that with 100% oxygen, 21 patients responded well to PEEP with a 52% mortality rate when arterial partial pressure of oxygen was 150 torr, whereas 24 patients showed poor or no response to PEEP when oxygen partial pressure was less than 70 torr , The mortality rate is 80%. In addition, the causes of increased mortality, in addition to ARDS, there are problems of sepsis itself and cardiac dysfunction. Age is also an important factor. Mortality rates in the under-20s range from 50% to over 65% to 81%.