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目的探讨中药益气活血方联合长春瑞滨和顺铂(NP方案)化疗治疗晚期非小细胞肺癌(NSCLC)的近期疗效。方法将2008年1月至2012年5月收治的93例的晚期NSCLC患者随机分为中药联合化疗组(45例)和单纯化疗组(48例),中药联合化疗组采用益气活血方联合NP化疗方案治疗,单纯化疗组采用NP化疗方案。21d为1个治疗周期,治疗3个周期后,对比两组患者临床症状、生活质量改善情况及不良反应。结果 (1)中药联合化疗组总体有效率(24.4%)和肿瘤控制率(82.2%)均高于单纯化疗组(18.8%及77.1%),但差异均无统计学意义(P>0.05)。(2)中药联合化疗组患者治疗后生活质量改善比例(35.6%)高于单纯化疗组(16.7%),差异有统计学意义(P<0.05),生活质量下降患者比例(15.6%)低于单纯化疗组(31.3%)。(3)中药联合化疗组患者胃肠道反应和白细胞下降者所占比例显著低于单纯化疗组,差异有统计学意义(P<0.05)。结论益气活血方联合NP化疗方案治疗晚期NSCLC与常规NP方案相比,可明显提高患者生活质量。
Objective To investigate the short-term curative effect of traditional Chinese medicine Yiqi Huoxue Recipe combined with vinorelbine and cisplatin (NP regimen) chemotherapy in the treatment of advanced non-small cell lung cancer (NSCLC). Methods Ninety-three patients with advanced NSCLC who were admitted from January 2008 to May 2012 were randomly divided into two groups: the combination chemotherapy group (n = 45) and the chemotherapy alone group (n = 48). The combination chemotherapy of Yiqi Huoxue prescription and NP Chemotherapy regimen, chemotherapy alone group with NP chemotherapy. 21d for a treatment cycle, the treatment of three cycles, the clinical symptoms of two groups compared to the quality of life improvement and adverse reactions. Results (1) The total effective rate (24.4%) and tumor control rate (82.2%) in the combination chemotherapy group were significantly higher than those in the chemotherapy group (18.8% and 77.1%, respectively), but the differences were not statistically significant (P> 0.05). (2) The improvement rate of quality of life (35.6%) in the combined chemotherapy group was significantly higher than that in the chemotherapy group (16.7%), the difference was statistically significant (P <0.05); the quality of life decreased Simple chemotherapy group (31.3%). (3) The proportion of gastrointestinal tract reaction and leukopenia in the combination chemotherapy group was significantly lower than that in the chemotherapy alone group (P <0.05). Conclusion Yiqi Huoxue prescription combined with NP chemotherapy in the treatment of advanced NSCLC patients with conventional NP compared to the program, can significantly improve the quality of life of patients.