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目的 观察猕猴眼内氟 肝素表面修饰的人工晶状体 (intraocularlens ,IOL)表面细胞的反应情况 ,研究修饰后IOL的生物相容性。方法 健康猕猴 10只 (2 0只眼 )分为修饰和未修饰两组 ,分别植入氟 肝素表面修饰和未修饰的IOL。于术后 180d和 36 0d对取出的IOL进行光镜、扫描电镜及计算机图像分析。结果 IOL光学中心表面黏附细胞较少 ,周边部黏附细胞较多。细胞黏附面积最大者为巨细胞 ,数量最多者为巨噬细胞。修饰组IOL表面黏附细胞少于未修饰组 ;修饰的IOL表面附着细颗粒样的蛋白膜 ,未修饰的IOL表面附着纤维网状及颗粒样的蛋白膜。结论 氟 肝素表面修饰的IOL生物相容性优于未修饰的IOL
Objective To observe the response of intraocular lens (IOL) surface cells in the eyes of Rhesus monkey and to study the biocompatibility of modified IOL. Methods Healthy macaque 10 eyes (20 eyes) were divided into two groups: modified and unmodified. Fluoroalphalone surface-modified and unmodified IOL were implanted. The extracted IOLs were examined by light microscopy, scanning electron microscopy and computer image analysis at 180 days and 36 days after operation. Results The IOL optical center had fewer adherent cells and more adherent cells in the periphery. The largest cell adhesion area for the giant cells, the largest number of macrophages. In the modified group, less adherent cells were found in the IOL than in the unmodified group. The fine IOL-like protein membrane adhered to the modified IOL surface and the fibrous reticular and granular protein membrane attached to the surface of the unmodified IOL. Conclusion The biocompatibility of Fluorolipid surface-modified IOL is better than that of unmodified IOL