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目的总结单纯巨核细胞再生障碍的临床特点,提高诊治水平。方法血液常规分析;骨髓涂片经瑞氏染色后细胞分类。结果骨髓涂片上无巨核细胞或巨核细胞显著减少,血小板计数在48×109/L以下,平均为22×109/L;出血症状明显,伴程度不同的贫血,少数有肝脾肿大。经治疗,3例痊愈,2例死亡,2例无变化。结论单纯巨核细胞再生障碍临床与血液学表现与原发性血小板减少性紫癜(ITP)有某些相似,注意二者的鉴别诊断有助于临床治疗与疾病的转归。
Objective To summarize the clinical features of simple megakaryocyte aplastic anemia and to improve the diagnosis and treatment. Methods Blood routine analysis; bone marrow smears by Wright’s stain cell classification. Results There were no megakaryocytes or megakaryocytes in the bone marrow smears. The platelet counts were below 48 × 109 / L with an average of 22 × 109 / L. The bleeding symptoms were obvious with varying degrees of anemia and a few with hepatosplenomegaly. After treatment, 3 patients recovered, 2 died, 2 patients did not change. Conclusions The clinical and hematological manifestations of simple megakaryocyte aplasia are somewhat similar to those of idiopathic thrombocytopenic purpura (ITP). It should be noted that the differential diagnosis between the two is helpful for the clinical treatment and the prognosis of the disease.