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目的:观察诱导化疗和同步放化疗在中晚期鼻咽癌治疗中的临床应用效果。方法:收集2015年2月-2016年2月我院收治的38例中晚期鼻咽癌患者,随机分为2组,观察组予诱导化疗,对照组予同步放化疗,比较两组疗效。结果:观察组24例,完全缓解5例,部分缓解10例,疾病稳定8例,疾病进展1例,治疗有效率62.5%;对照组14例,完全缓解0例,部分缓解8例,疾病稳定4例,疾病进展2例,治疗有效率57.1%(P>0.05)。观察组皮肤黏膜损伤:1级16例,2级6例,3级2例;唾液腺毒性:0级17例,1级7例;对照组皮肤黏膜损伤:1级2例,2级8例,3级4例;唾液腺毒性:0级2例,1级7例,2级5例(P<0.05)。结论:诱导化疗在中晚期鼻咽癌治疗中的临床效果显著,毒性反应小,值得临床推广。
Objective: To observe the clinical application of induction chemotherapy and concurrent chemoradiotherapy in the treatment of advanced nasopharyngeal carcinoma. Methods: Thirty-eight patients with advanced nasopharyngeal carcinoma admitted to our hospital from February 2015 to February 2016 were randomly divided into two groups. The observation group received induction chemotherapy and the control group received concurrent chemoradiotherapy. The curative effect was compared between the two groups. Results: The observation group of 24 cases, complete remission in 5 cases, partial remission in 10 cases, stable disease in 8 cases, disease progression in 1 case, the effective rate of 62.5%; control group of 14 patients, complete remission in 0 cases, partial remission in 8 cases, stable disease 4 cases, 2 cases of disease progression, the effective rate of treatment was 57.1% (P> 0.05). In the observation group, the skin and mucosal injury were as follows: grade 1 in 16 cases, grade 2 in 6 cases and grade 3 in 2 cases; salivary gland toxicity: grade 0 in 17 cases and grade 1 in 7 cases; skin and mucosal injury in control group: grade 1 in 2 cases, grade 2 in 8, Grade 3 in 4 cases; salivary gland toxicity: 0 in 2 cases, grade 1 in 7 cases, grade 2 in 5 cases (P <0.05). Conclusion: Induction chemotherapy in the treatment of advanced nasopharyngeal carcinoma clinical effect is significant, the toxicity of small, worthy of clinical promotion.