目的探讨结节型淋巴细胞为主型霍奇金病临床病理诊断特征。方法结节型淋巴细胞为主型霍奇金病淋巴结石蜡包埋组织11例。除H..E切片外，还用抗CD3，CD19，CD20，CD30，CD45RB及κ，λ单克隆抗体进行ABC法免疫组织化学标记。结果肿瘤组织以结节状排列的小淋巴细胞和组织细胞为背景，其间散在分布L＆H细胞。L＆H细胞表达CD19（10／11），CD20（11／11），CD45RB（11／11）及κ轻链（10／11）。8例病人（73％）随访期超过5年以上。结论结节型淋巴细胞为主型霍奇金病临床经过非常缓慢，预后良好，其实质是一种特殊的B细胞肿瘤。 Objective To investigate the clinicopathological features of nodular lymphocyte predominant Hodgkin’s disease. Methods Nodular lymphocytes were predominantly Hodgkin’s disease. Lymph node paraffin-embedded tissue was found in 11 cases. In addition to the H..E slices, anti-CD3, CD19, CD20, CD30, CD45RB, and kappa, lambda monoclonal antibodies were also used for ABC immunohistochemical labeling. RESULTS: The tumor tissues consisted of nodule-like small lymphocytes and histiocytes, with scattered L&H cells. L&H cells express CD19 (10/11), CD20 (11/11), CD45RB (11/11) and Kappa light chain (10/11). Eight patients (73%) had a follow-up period of more than 5 years. Conclusion Nodular lymphocyte-predominant Hodgkin’s disease has a very slow clinical history and a good prognosis. The substance is a special type of B-cell tumor.