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目的探讨慢性肺源性心脏病合并消化道出血的临床效果。方法将90例慢性肺源性心脏病合并消化道出血患者随机分为观察组与对照组各45例,均接受平喘、镇咳、祛痰等常规治疗,观察组在此基础上接受H2受体阻滞剂治疗。比较2组临床疗效、消化道出血停止时间及不良反应发生情况。结果观察组治疗总有效率为91.1%高于对照组的66.7%,差异有统计学意义(P<0.05)。观察组患者消化道出血停止时间为(15.23±3.25)h短于对照组患者的(20.67±4.11)h,差异有统计学意义(P<0.05)。观察组患者治疗期间出现乏力1例、腹泻1例、头痛1例,不良反应发生率为6.7%,对照组患者治疗期间未出现不良反应,组间比较差异无统计学意义(P>0.05)。结论在慢性肺源性心脏病合并消化道出血常规治疗的基础上采用H2受体阻滞剂能够快速止血,改善预后,具有显著使用价值。
Objective To investigate the clinical effect of chronic cor pulmonale combined with gastrointestinal bleeding. Methods Ninety patients with chronic cor pulmonale complicated by gastrointestinal hemorrhage were randomly divided into observation group and control group, with 45 patients receiving conventional therapy such as asthma, antitussive and expectorant. The observation group received H2 receptor Body blocker treatment. The clinical curative effect, the stop time of gastrointestinal bleeding and the occurrence of adverse reactions were compared between the two groups. Results The total effective rate of observation group was 91.1% higher than 66.7% of control group, the difference was statistically significant (P <0.05). The observation group patients with gastrointestinal bleeding stop time (15.23 ± 3.25) h shorter than the control group (20.67 ± 4.11) h, the difference was statistically significant (P <0.05). In the observation group, 1 case of fatigue, 1 case of diarrhea, 1 case of headache and 6.7% of adverse reactions occurred in the treatment group. There was no adverse reaction during the treatment in the control group. There was no significant difference between the two groups (P> 0.05). Conclusions The use of H2 blockers on the basis of conventional treatment of chronic cor pulmonale combined with gastrointestinal bleeding can rapidly stop bleeding and improve prognosis, which has significant value.