目的 :探讨舒心注射液对心肌缺血再灌注损伤的保护作用。方法 :对初次发病且发病后 36小时内的10 1例急性心肌梗死患者采用舒心注射液治疗 1周 ,观察治疗前后血清中红细胞超氧化物歧化酶 (SOD)、血浆乳酸脱氢酶 (L DH)活性及丙二醛 (MDA)含量的变化。将 2 0只心肌缺血再灌注模型兔随机分为缺血再灌注对照组和舒心注射液治疗组 ,每组各 10只。治疗组于缺血 10分钟时从耳缘静脉注入舒心注射液 2 m l/kg,对照组注入生理盐水 2 m l/kg,实验过程中记录左心室收缩内压 (L VSP) ,左室内压最大变化速率 (± dp/dt)及心电图 导联 ST段 ,测定血浆肌酸磷酸激酶 (CPK)活性和 MDA含量。结果 :急性心肌梗死患者用舒心注射液治疗后 ,SOD活性明显升高 (P<0 .0 1) ,L DH活性及 MDA含量明显降低 (P<0 .0 1)。动物缺血 40分钟及再灌注 40分钟时 ,治疗组 L VSP、± dp/dt值高于对照组 ,ΣST段、血浆 CPK活性和 MDA含量均明显低于对照组 (P均<0 .0 1)。结论 :舒心注射液对心肌缺血再灌注损伤有明显治疗作用 ,其机制可能与减轻氧自由基损伤有关。 Objective: To investigate the protective effect of Shuxin injection on myocardial ischemia-reperfusion injury. METHODS: One hundred and one patients with acute myocardial infarction within 36 hours after onset and within 36 hours after onset were treated with Shuxin injection for one week. Serum red cell superoxide dismutase (SOD) and plasma lactate dehydrogenase (LDH) were observed before and after treatment. ) Changes in activity and malondialdehyde (MDA) content. Twenty rabbits were randomly divided into ischemia-reperfusion control group and Shuxin injection treatment group, 10 in each group. The treatment group was injected with 2 ml/kg Shuxin Injection from the ear vein at 10 minutes of ischemia, and the control group was injected with 2 ml/kg physiological saline. The left ventricular contraction pressure (L VSP) was recorded during the experiment, and the maximum left ventricular pressure was changed. The rate (±dp/dt) and the ST segment of the ECG lead were used to measure plasma creatine kinase (CPK) activity and MDA content. RESULTS: After treatment with Shuxin injection in patients with acute myocardial infarction, SOD activity was significantly increased (P<0.01), LDH activity and MDA content were significantly decreased (P<0.01). After 40 minutes of animal ischemia and 40 minutes of reperfusion, the L VSP and ±dp/dt values ​​in the treatment group were higher than those in the control group, and the ST segment and plasma CPK activity and MDA content in the treatment group were significantly lower than those in the control group (P<0.01. ). Conclusion : Shuxin injection has obvious therapeutic effect on myocardial ischemia-reperfusion injury. The mechanism may be related to the reduction of oxygen free radical injury.