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目的:观察三苯氧胺促排卵治疗的临床疗效。方法:符合标准的87例患者服用三苯氧胺治疗,记录卵泡成熟、排卵、子宫内膜生长、宫颈黏液性状、妊娠及流产等指标。并与同期使用克罗米酚(CC)治疗的患者进行比较。结果:三苯氧胺促排卵治疗125周期中,成熟卵泡数115个,经注射人绒毛膜促性腺激素(hCG)48～60 h卵泡破裂,排卵104个,排卵率90%,子宫内膜三线征101例,宫颈黏液平均11.52分,9例发生黄素化未破裂卵泡综合征(LUFS),妊娠率29%,流产率8.00%,未出现卵巢过度刺激综合征(OHSS)。无一例发生畸形。结论:三苯氧胺有促卵泡生长作用,排卵率高,使子宫内膜三线征出现率高,妊娠率高,流产率低,对宫颈黏液影响小,经济、方便、安全,效果好,副作用小。
Objective: To observe the clinical efficacy of tamoxifen in ovulation induction therapy. Methods: Eighty - seven patients were treated with tamoxifen. The indexes of follicular maturation, ovulation, endometrial growth, cervical mucus trauma, pregnancy and miscarriage were recorded. And compared with patients treated with clomiphene citrate (CC) over the same period. Results: In the 125 cycles of tamoxifen ovulation therapy, the number of mature follicles was 115. The follicles were ovulated 104 times, ovulation rate 90% and endometrial trigeminal levy 101 cases by 48 h-60 h injection of hCG (human chorionic gonadotropin) , Cervix mucus average 11.52 points, 9 cases of luteinized unruptured follicular syndrome (LUFS), pregnancy rate of 29%, abortion rate of 8.00%, no ovarian hyperstimulation syndrome (OHSS). No one had deformity. Conclusion: Tamoxifen has the effect of promoting follicular growth, high ovulation rate, high incidence of third trimester of endometrium, high pregnancy rate, low abortion rate, small effect on cervical mucus, economical, convenient, safe and effective with small side effects.