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目的 :以大样本人群队列为基础,探讨常州农村地区人群高血压发病的相关危险因素,为高血压的早期防治提供参考依据。方法:采用巢式病例对照研究,选取常州市武进区慢性病队列中经两次随访新发高血压患者作为病例组(3 400例),按照性别、年龄进行频数匹配(1∶1),随机选取3 400例基线和两次随访均未患高血压的正常样本为对照,高血压的相关影响因素分析采用单因素和多因素Logistic回归分析。结果:单因素Logistic回归结果表明,饮酒、体重指数、总胆固醇和甘油三酯与高血压的发病相关;进一步多因素Logistic回归结果显示,饮酒、超重、肥胖、总胆固醇和甘油三酯异常可增加高血压的发病风险,而低体重为高血压的保护因素。结论:饮酒、超重或肥胖、血脂异常可能是影响常州农村地区高血压发病的危险因素,应当针对重点人群进行早期干预,降低高血压发病风险。
OBJECTIVE: To explore the risk factors of hypertension in rural population of Changzhou based on the cohort of large sample population, and to provide a reference for the early prevention and treatment of hypertension. Methods: A nested case-control study was conducted. The patients with chronic hypertension in Wujin District of Changzhou City were enrolled as new cases of hypertension (3 400 cases), matched by frequency and sex (1: 1) by gender and age, randomly selected 3 400 normal subjects who did not have hypertension at baseline and two follow-up were taken as control. The related factors of hypertension were analyzed by single factor and multivariate logistic regression analysis. Results: Logistic regression analysis showed that alcohol consumption, body mass index, total cholesterol and triglyceride were associated with the incidence of hypertension. Further multivariate Logistic regression showed that alcohol, overweight, obesity, total cholesterol and triglyceride abnormalities increased The risk of developing hypertension, and low body weight as a protective factor of hypertension. Conclusion: Alcohol consumption, overweight or obesity and dyslipidemia may be the risk factors of hypertension in rural areas of Changzhou. Early intervention should be conducted in key populations to reduce the risk of hypertension.