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目的:系统评价左旋甲状腺素（LTn 4）治疗对甲状腺功能正常的甲状腺自身抗体阳性妇女妊娠结局的影响。n 方法:检索Medline数据库、荷兰医学文摘（EMBASE）数据库、Cochrane图书馆（Cochrane Library）数据库、中国知网（CNKI）数据库、中国生物医学文献数据库（CBM）、万方数据库和维普数据库，搜集公开发表的评估补充LTn 4对甲状腺功能正常的甲状腺自身抗体阳性妇女妊娠结局影响的随机对照研究，检索时限从建库至2020年1月28日。应用STATA 11.0和RevMan 5.3软件进行荟萃分析（Meta分析）。n 结果:最终纳入6篇文献，共涉及甲状腺功能正常的甲状腺自身抗体阳性孕妇2 188例，其中1 092例接受了LTn 4治疗，1 096例未接受LTn 4治疗。Meta分析结果显示，针对甲状腺功能正常的甲状腺自身抗体阳性妇女，LTn 4治疗组与对照组的流产率（n OR=0.85，95%n CI为0.65~1.11，n P=0.234）和早产率（n OR=0.79，95%n CI为0.54~1.16，n P=0.224）差异均无统计学意义。n 结论:LTn 4治疗不能降低甲状腺功能正常的甲状腺自身抗体阳性孕妇的流产和早产风险，对于这类孕妇应慎用LTn 4治疗。n “,”Objective:To conduct a systematic review of the association of levothyroxine treatment with pregnancy outcomes in euthyroid women who are thyroid autoantibody positive.Methods:Medline, Excerpta Medica (EMBASE), Cochrane Library, China National Knowledge Infrastructure (CNKI), China Biology Medicine (CBM), Wanfang data and VIP database were searched from inception until Jan. 28, 2020. All published randomized controlled trials assessing the association of levothyroxine treatment with pregnancy outcomes in euthyroid women with thyroid autoantibody-positive were included. STATA 11.0 and RevMan 5.3 softwares were used to perform this Meta-analysis.Results:A total of 6 studies met the inclusion criteria, with 2 188 women randomized. Meta-analysis showed that there was no significantly association between miscarriage (n OR=0.85, 95%n CI: 0.65-1.11, n P=0.234) and preterm birth (n OR=0.79, 95%n CI: 0.54-1.16, n P=0.224) with levothyroxine treatment.n Conclusions:Levothyroxine therapy could not reduce the risk of miscarriage and preterm birth in euthyroid women with thyroid autoantibody-positive. Therefore, levothyroxine should be used with caution for these pregnant women.