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本研究显示维甲酸（ＲＡ）能明显增加人脐带血管内皮细胞（ＨＵＶＥＣｓ）血栓调节蛋白（ＴＭ）、组织纤溶酶原激活物（ｔ－ＰＡ）和前列环素（ＰＧＩ＿２）的分泌与合成，此种作用呈现时间及剂量依赖性。ＲＡ作用２４小时后可使ＴＭ及ＰＧＩ＿２分泌较初始分别增加３～４倍及７倍左右。癌性促凝物（ＣＰ）与肿瘤坏死因子（ＴＮＦα）作用类似。对ＴＭ呈现抑制作用，对ｔ－ＰＡ及ＰＧＩ＿２则有促进分泌与合成的作用，其中以ＣＰ为明显。ＣＰ尚有抑制ｖＷＦ的作用。联合ＲＡ与ＣＰ或ＴＮＦα一起培养，ＲＡ可逆转后二者对ＴＭ的抑制作用，改变ＣＰ对ｔ－ＰＡ及ｖＷＦ的影响。
This study showed that retinoic acid (RA) significantly increased the secretion and synthesis of thrombomodulin (TM), tissue plasminogen activator (t-PA) and prostacyclin (PGI_2) in human umbilical cord endothelial cells (HUVECs) This effect showed time and dose-dependent. After 24 hours, the secretion of TM and PGI_2 increased by 3 ~ 4 times and 7 times respectively. Cancerous coagulants (CP) function similarly to tumor necrosis factor (TNFα). On the TM showed inhibition of t-PA and PGI_2 have a role in promoting secretion and synthesis, of which CP was obvious. CP still has the effect of inhibiting vWF. The combined RA and CP or TNFα cultured together, RA can be reversed after the inhibition of TM, changing the impact of CP on t-PA and vWF.