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酮康唑系合成的咪唑类抗真菌药,临床用于治疗表皮和深部真菌病,也可用于预防白色念珠菌病的再发以及由于免疫功能低下而引起的真菌感染。本品常见的不良反应有恶心、呕吐、瘙痒、腹痛、头痛及嗜睡等,其中最突出的是引起肝损害,甚至引起死亡,临床应用需引起高度重视。国内有关调查发现酮康唑引起的肝功异常,常发生在服药30天左右。有报道一例58岁女患者,就诊前两个月因甲癣自服酮康唑治疗,0.2克/日,而导致了严重的肝损害,入院经多方治疗无效,最终死于中毒性肝炎所致肝肾功能衰竭。另有报道一患有泛发性体癣的24岁男性患者,口服酮康唑治疗,0.2克/次,1次/日,并外用酮康唑霜
Ketoconazole synthetic imidazole antifungal agents, clinical treatment of epidermal and deep fungal disease, can also be used to prevent the recurrence of Candida albicans and due to immune dysfunction caused by fungal infections. Common side effects of this product are nausea, vomiting, itching, abdominal pain, headache and drowsiness, which is the most prominent cause liver damage, and even cause death, the clinical application of the need for attention. Domestic investigation found that ketoconazole caused by abnormal liver function, often occurs in about 30 days medication. It has been reported that a 58-year-old female patient had severe liver damage caused by onychomycosis ketoconazole two months prior to the first visit and was ineligible for multi-party admission and finally died of toxic hepatitis Liver and kidney failure. Another report of a 24-year-old man suffering from generalized tinea pedis, oral ketoconazole treatment, 0.2 g / time, 1 / day, and topical ketoconazole cream