将羊红细胞注入小鼠尾静脉引起初次免疫应答,此时下丘脑神经肽Y含量明显升高,神经肽Y受体表达显著增加(p<0.05),同时去甲肾上腺素降低,高香草酸明显升高(p<0.05)。腹腔注入ConA刺激的脾细胞和U_(937)细胞上清得到类似结果。该结果提示神经肽Y可能参与免疫应答过程中免疫活性分子影响中枢神经系统活动的介导作用。 The injection of sheep red blood cells into the tail vein of mice caused a primary immune response, when the hypothalamic neuropeptide Y levels were significantly increased, neuropeptide Y receptor expression was significantly increased (p <0.05), while norepinephrine decreased hyperovarnate significantly increased High (p <0.05). Similar results were obtained by intraperitoneal injection of ConA-stimulated splenocytes and U937 cell supernatant. This result suggests that neuropeptide Y may be involved in the mediation of immune activity affecting central nervous system activity during immune response.