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药源性死亡(drug-induced death,DID)系指健康的人或病情平稳的患者在疾病的预防、诊断或治疗过程中,因用药后出现药品不良反应(ADR)而引起的死亡(不包括因原患疾病或与ADR无关的死亡).我国ADR监察中心报告的1833例药源性疾病中,死亡29例,死亡率为1.58%,且每年约有250万人因ADR而住院,其中19.22万人死亡,死亡率为7.69%.鉴于DID的严重性,加强药学监护减少DID的发生尤为必要,但至今未见国内文献中有关DID病例调研较系统的分析.本文就1985～1994年度国内公开发行的20种期刊1709期中登载的454例DID进行分析和评价,试图通过对死者的性别、年龄、致死药品、剂型、给药途径和致死药源性疾病等因素的探讨,以初步了解诸因素与DID间的关系,奢望能为我国开展药品流行病学的研究提供某些参考.
Drug-induced death (DID) refers to death caused by adverse drug reactions (ADR) in the course of the prevention, diagnosis or treatment of a disease in a healthy person or a stable patient (excluding Due to the original disease or ADR unrelated deaths.) China’s ADR monitoring center reported 1833 cases of drug-induced diseases, 29 deaths, the mortality rate was 1.58%, and about 2.5 million people were hospitalized each year due to ADR, of which 192,200 The death rate is 7.69% .Due to the seriousness of DID, strengthening the medical supervision to reduce the occurrence of DID is especially necessary, but so far there is no systematic analysis of the DID case investigation in the domestic literature.This article on 1985-1994 domestic public offering 454 cases of DID published in 1709 periodicals of 20 journals were analyzed and evaluated in order to explore the factors such as sex, age, lethal drug, dosage form, route of administration and drug-induced drug-induced diseases, DID relationship, hope can provide some reference for our country to carry out the study of drug epidemiology.