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目的探讨儿童尿路感染常见病原菌的种类分布及耐药现状,为临床医师抗感染治疗选择敏感的抗菌药物提供参考依据。方法无菌手法采集2010年1月-2013年12月在鄂州市两所医院就诊的尿路感染患儿清洁中段尿或导尿标本3 937份,进行尿液细菌计数、定量培养、细菌鉴定;药敏试验采用纸片扩散法(K-B法),数据采用WHONET 5.6软件进行统计分析。结果 3 937份标本中检出病原菌197株,阳性检出率为5.0%;以大肠埃希菌为主占39.1%,其次凝固酶阴性葡萄球菌占17.8%;碳青霉烯类药物对革兰阴性菌保持了100.0%的抗菌活性,产超广谱β-内酰胺酶(ESBLs)细菌检出率为37.1%,耐甲氧西林葡萄球菌(MRS)检出率为36.6%。结论儿童尿路感染病原菌的种类与成人尿路感染病原菌相似,其耐药性呈上升趋势,应采取有效措施进行细菌耐药性的干预。
Objective To explore the distribution and drug resistance status of common pathogens in children with urinary tract infection and provide references for clinicians to choose antimicrobial agents that are sensitive to anti-infection. Methods A total of 3 937 urinary tract or catheter specimens of urinary tract infection from January 2010 to December 2013 in two hospitals of Ezhou were collected by aseptic technique. The urine bacterial count, quantitative culture and bacterial identification were performed. Drug sensitivity test using disk diffusion method (KB method), the data using WHONET 5.6 software for statistical analysis. Results A total of 197 strains of pathogens were detected in 3 937 samples, the positive rate was 5.0%. Escherichia coli accounted for 39.1%, followed by coagulase-negative staphylococci accounted for 17.8%. The carbapenems against Gram The negative bacteria maintained 100.0% antibacterial activity. The detection rate of extended-spectrum β-lactamase (ESBLs) producing bacteria was 37.1% and that of methicillin-resistant staphylococcus aureus (MRS) was 36.6%. Conclusion The pathogen of urinary tract infection in children is similar to the pathogens of urinary tract infection in adults, and its drug resistance is on the rise. Effective measures should be taken to interfere with bacterial resistance.