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目的分析单唾液酸神经节苷脂治疗新生儿缺氧缺血性脑病(HIE)效果。方法 70例HIE新生儿,采用随机数字表法分为对照组和观察组,各35例。两组患儿均给予常规三项支持治疗等,观察组在此基础上联合单唾液酸神经节苷脂治疗。比较两组患儿治疗效果、新生儿20项行为神经评定(NBNA)评分、末次随访婴幼儿智能发育检查量表(CDCC)评分。结果观察组显效率为85.71%,高于对照组的60.00%,差异有统计学意义(P<0.05)。观察组随访(6.1±1.3)个月,对照组(6.0±1.5)个月。治疗第7、14天,两组患儿NBNA评分均高于治疗前,且观察组患儿高于对照组,差异具有统计学意义(P<0.05);两组末次随访CDCC评分比较差异无统计学意义(P>0.05)。结论单唾液酸神经节苷脂治疗新生儿HIE有助于神经功能恢复,改善颅脑灌注。
Objective To analyze the effect of monosialoganglioside on neonatal hypoxic-ischemic encephalopathy (HIE). Methods Seventy neonates with HIE were divided into control group and observation group by random number table, 35 cases each. Two groups of children were given conventional three supportive treatment, the observation group on this basis combined monosialoganglioside treatment. The therapeutic effects of the two groups were compared, 20 neonates with behavioral neurological assessment (NBNA) score, the last follow-up infant mental development examination scale (CDCC) score. Results The effective rate of the observation group was 85.71%, which was higher than that of the control group (60.00%), the difference was statistically significant (P <0.05). The observation group was followed up (6.1 ± 1.3) months and the control group (6.0 ± 1.5) months. On the 7th and 14th days of treatment, the NBNA scores of the two groups were higher than those before treatment, and the children in the observation group were higher than the control group (P <0.05). There was no significant difference in the scores of CDCC between the two groups Significance (P> 0.05). Conclusion Monosialoganglioside treatment of neonatal HIE helps to restore neurological function and improve cerebral perfusion.