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本研究在国内首次发现异常增高的循环白介素６ 可导致狼疮性全身性病理损害；白介素６ 异常增高在狼疮性小管间质损害过程中可能具有重要作用；白介素６ 及其信息传递中的 Ｇ Ｐ１３０ ， Ｊｕｎ Ｂ 基因异常表达参与了弥漫性增生性狼疮性肾炎（ Ｌ Ｎ） 分子发病过程，并率先发现丹参通过增强ｃｍｙｃ 蛋白高水平表达而诱导细胞凋亡，从而对人肾成纤维细胞增殖产生抑制作用。在国内外首次证实巨噬细胞在 Ｌ Ｎ 的病人肾脏局部增殖，且和疾病严重程度呈正相关。首次发现白介素受体（ｓ Ｉ Ｌ２ Ｒ） 和 Ｆ Ｌ Ｃ Ｔ 增多是诊断早期活动 Ｌ Ｎ 的可靠指标。筛选并建立了一种本病活动性的计分方法；发现小管间质病变分级对 Ｌ Ｎ 肾小球病理、临床表现、治疗、疗效及复发的判断均有指导意义。在国内首先报道超大剂激素冲击疗法治疗严重的活动性 Ｌ Ｎ，率先提出适合我国国情的改进 Ｃ Ｔ Ｘ 冲击疗法治疗 Ｌ Ｎ。发现中药在促进骨髓造血，对抗 Ｃ Ｔ Ｘ 等致免疫功能过度抑制具有一定作用。首次在国内探讨了 Ｌ Ｎ 尿毒症的可逆性，并分析发现 Ｓ Ｌ Ｅ 死亡最主要原因并非尿毒症。
This study found for the first time in China the abnormal increase of circulating interleukin-6 can lead to systemic pathological lesions of lupus; interleukin -6 abnormal increase in lupus tubulointerstitial damage may play an important role; interleukin 6 and its information transmission G P130, Jun B gene abnormal expression is involved in the pathogenesis of diffuse lupus nephritis (L N) molecule, and the first discovery of Salvia by high c cmyc protein expression and induce apoptosis, thereby human renal fibrosis Cell proliferation inhibition. For the first time at home and abroad confirmed local proliferation of macrophages in the kidney of patients with LN, and with the severity of the disease was positively correlated. For the first time found that interleukin receptors (s I L 2 R) and increased F LC is a reliable indicator of early diagnosis of L N. We screened and established a scoring method for the activity of this disease. It was found that the classification of tubulointerstitial lesions has guiding significance for the pathological, clinical manifestation, treatment, curative effect and recurrence of LN. In the country first reported that large doses of hormones impact therapy for the treatment of serious activity L N, the first to put forward the appropriate CTL impact therapy for our country’s condition treatment of LN. Found that Chinese medicine in promoting bone marrow hematopoietic, anti-C T X and other over-suppressed immune function has a role. For the first time in China to explore the reversibility of L N uremia, and analysis found that the leading cause of death of S L E is not uremia.